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After a year taking Amantadine his parkinsonism worsens, andhis mobility is poor: he is finding it difficult to get to workon the bus.
- What other drug treatment might you consider?
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- Anticholinergics
- Sinemet/Madopar
- Selegiline
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- Are there any problems with these drugs? How might you overcome them?
- Dry mouth
- Nausea
- Blurred vision
- Anorexia
- Vomiting
- Urinary retention
- Hypotension
- Constipation
- Confusion
- Confusion
- Hypotension
- Dyskinesia
- Dystonic reactions
- Reduce dose
- On-off Phenomenon
- Build dose up
- Stop drug
- Monitor for Post-dose bradykinesia
- More frequent Smaller doses Add Selegiline – reduce dose by one third
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